Hepato-Pancreato-Biliary (HPB) cancer

What is Hepato-Pancreato-Biliary (HPB) cancer

The Hepato-Pancreato-Biliary (HPB) cancer category incorporates a wide range of gastrointestinal malignancies including pancreatic, liver, biliary, gallbladder cancers. Normally, they are primary malignancies except in the liver which can have metastasis from several other malignancies.

Below is the list of common Hepato-Pancreato-Biliary diseases and their causes:

Liver cancer

Also known as hepatocellular carcinoma, liver cancer is induced by extreme alcohol consumption, birth defects that affect the liver, or chronic hepatitis diseases. It is also associated with hemochromatosis, a hereditary disease causing abnormally high levels of iron in the liver.

Biliary disease

  • Gallstones – The formation of stones in the gallbladder is often due to huge levels of cholesterol in the bile that the gallbladder freeing.
  • Gallbladder cancer – The risk of gallbladder cancer is higher amongst patients who have gallstones or suffer from persistent or recurrent cholecystitis.
  • Bile duct cancer – Cancer of the bile duct occurs often due to cholangitis or sclerosis of the bile ducts.
  • Cholangitis – This is a condition identified by the inflammation of the bile ducts.
  • Cholecystitis – This is a condition identified by the inflammation of the gallbladder.

Pancreatic disease

  • Pancreatic cancer – This is a disease wherein the cells in the pancreas develop abnormal DNA mutations. As many as one-fourth of all pancreatic cancer cases are caused by cigarette smoking.

Hepato-Pancreato-Biliary Cancer Types

Symptoms Related to Hepato-Pancreato-Biliary (HPB) cancer are:

  • Jaundice
  • Abdominal pain and swelling
  • Itchy skin
  • Blood in the stool
  • Legs and ankle swelling
  • Vomiting and Nausea
  • Loss of appetite

Treatment Overview

Patients undergoing from Hepato-Pancreato-Biliary diseases should first discuss with the hepatologist. Depending on the severity and staging of the disease, your doctor would suggest a hepatobiliary surgeon. The surgeon will then analyze the case and start with one of the various treatment options and so on. Contact our expert Oncoxpert team to get into more details regarding the treatment options for this complex disease.

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